Pseudocholinesterase activity and atracurium v. suxamethonium block.
نویسندگان
چکیده
Serum pseudocholinesterase activity in pregnant women was assayed spectrophotometrically using either propionylthiocholine or suxamethonium as substrate. All patients had a normal phenotype as indicated by normal dibucaine and fluoride numbers. However, the mean cholinesterase activity was lower than in the general population. There was a negative correlation between cholinesterase activity and the duration of neuromuscular blockade following suxamethonium, but no correlation was observed between the cholinesterase activity and the duration of block following atracurium.
منابع مشابه
Pharmacokinetics and pharmacodynamics of atracurium with and without previous suxamethonium administration.
Suxamethonium increases neuromuscular block produced by non-depolarizing agents administered subsequently. To determine if this effect has a pharmacokinetic or pharmacodynamic origin, 18 ASA physical status I or II adults received atracurium 0.2 mg kg-1, with (n = 10) or without (n = 8) previous injection of suxamethonium 1 mg kg-1, during a thiopentone-nitrous oxide-isoflurane (0.5% end-tidal)...
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I.v. atracurium 0.3 mg kg-1 and suxamethonium 1.6 mg kg-1 plus infusion were compared for use in outpatient laparoscopy. Thirty patients were randomly assigned to receive one of the two blocking drugs. Both drugs proved suitable for use in outpatient laparoscopy, but atracurium may have advantages if the operation proceeds directly to laparotomy.
متن کاملSerum cholinesterase: effect on the action of suxamethonium following administration to a patient with cholinesterase deficiency.
Purified serum cholinesterase 90 mg was administered to a patient with cholinesterase deficiency. The effect on the action of suxamethonium was studied. The half-life (44.7 h), time constant (64.5 h), rate constant (0.0155 h-1) and distribution volume (2740 ml) of the cholinesterase activity were determined.
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ورودعنوان ژورنال:
- British journal of anaesthesia
دوره 58 Suppl 1 شماره
صفحات -
تاریخ انتشار 1986